Clinical efficacy of Longidaze for the prevention of cicatricial and sclerotic complications after surgery on the upper urinary tract

Results of surgical treatment of patients with ureteral obstruction are not always successful. Prevention of cicatricial and sclerotic complications in the postoperative period plays an important role. In this connection, search for pathogenetic methods that prevent the recurrence of strictures is o...

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Published inUrologii͡a︡ (Moscow, Russia : 1999) no. 2; p. 18
Main Authors Avdoshin, V P, Andriukhin, T A, Zaĭtseva, I V, Rusakova, T I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2013
Subjects
Adolescent
Adult
Aged
Cicatrix - pathology
Cicatrix - prevention & control
Female
Follow-Up Studies
Humans
Hyaluronoglucosaminidase - administration & dosage
Hydronephrosis - pathology
Hydronephrosis - surgery
Laser Therapy - methods
Male
Middle Aged
Postoperative Complications - pathology
Postoperative Complications - prevention & control
Sclerosis
Ureteral Obstruction - pathology
Ureteral Obstruction - surgery
Urologic Surgical Procedures - adverse effects
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Summary:Results of surgical treatment of patients with ureteral obstruction are not always successful. Prevention of cicatricial and sclerotic complications in the postoperative period plays an important role. In this connection, search for pathogenetic methods that prevent the recurrence of strictures is one of the urgent problems of modern urology. 80 patients, divided into two groups (study and control), each of which was divided into three subgroups depending on the cause and degree of hydronephrosis, were followed-up. The first group consisted of patients with congenital hydronephrosis, the second group consisted of patients who underwent gynecological surgery with development of ureterohydronephrosis as complication. The third group consisted of patients with urolithiasis. All patients received surgical treatment. In postoperative period, active prevention of cicatricial and sclerotic complications in study group of 44 patients was performed. The control group consisted of 36 patients with history of surgery on the upper urinary tract without active antisclerotic prevention in the postoperative period. After interventions on urinary tract, comprehensive postoperative prevention of cicatricial and sclerotic complications using drug Longidaze 3000 IU for 10 injections intramuscularly 1 time every 3 days in combination with magnetic-laser therapy is recommended.
ISSN:1728-2985