ASSESSMENT OF SPECIFIC PHARMACOLOGIC ACTIVITY OF UNIFUSOL ON ENDOTHELIUM DYSFUNCTION MODEL INDUCED BY N-NITRO-L-ARGININE METHYL ETHER.

Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes i...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 79; no. 11; p. 11
Main Authors Vasil'evl, A G, Trashkov, A R, Verlov, N A, Kovalenko, A L, Petrov, A Yu, Valeev, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2016
Subjects
Animals
Antihypertensive Agents - therapeutic use
Arginine - analogs & derivatives
Arginine - therapeutic use
Biomarkers - blood
Blood Pressure - drug effects
Disease Models, Animal
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Male
NG-Nitroarginine Methyl Ester - toxicity
Nitric Oxide - blood
Rats
Succinates - therapeutic use
Vascular Diseases - blood
Vascular Diseases - drug therapy
Vascular Diseases - physiopathology
Vasodilator Agents - therapeutic use
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Summary:Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes in the arterial pressure level, duration of endothelium-dependent and -independent vasodilation, and the blood concentration of endothelial dysfunction markers including VEGF, NO, endothelin-I and the number of desquamated endotheliocytes. Administration of unifusol favors correction of blood vessel endothelium state manifested by normalization of its functional activity and reduction of the apoptosis of endotheliocytes. In addition, the obtained results unambiguously confirm considerable vasodilating and antihypertensive effects of unifusol.
ISSN:0869-2092