Infection and neuromyelitis optica spectrum disorders

The pathogenesis of neuromyelitisoptica spectrum disorders (NMOSD) is influenced by a combination of genetic and environmental factors, including infectious agents. Several viral and bacterial infectious diseases are related to the onset and the relapse of NMOSD.The cases of NMOSD with bacterial men...

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Published inZhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 45; no. 2; p. 181
Main Authors Hou, Dan, Yang, Guoshuai, Guo, Tie, Zhou, Feng, Yu, Dan
Format Journal Article
LanguageChinese
English
Published China 28.02.2020
Subjects
neuromyelitisoptica spectrum disorders
infection
viral
bacterial
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Summary:The pathogenesis of neuromyelitisoptica spectrum disorders (NMOSD) is influenced by a combination of genetic and environmental factors, including infectious agents. Several viral and bacterial infectious diseases are related to the onset and the relapse of NMOSD.The cases of NMOSD with bacterial meningitis have also been reported. Different infections play different role and outcomes in NMOSD.However,the major pathogenesis contains bystander activation, molecular mimicry, and systemic infection triggering independent central nervous system diseases. Viral and bacteria infections are closely related to NMOSD.We recommend that patients with NMOSD and altered mental status need to complete infectious examination, including a lumbar cone puncture.
ISSN:1672-7347
DOI:10.11817/j.issn.1672-7347.2020.190006