Evaluating Dengue Virus Pathogenesis in Mice and Humans by Histological and Immunohistochemistry Approaches

The analysis of dengue virus (DENV) infected tissues in mice experimental model and in human biopsies/autopsies may support the pathogenesis studies. Through such models, it is possible to investigate possible histopathological changes caused by the infection and detections of different targets of i...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2409; p. 259
Main Authors Salomão, Natália G, Rabelo, Kíssila, Paes, Marciano V
Format Journal Article
LanguageEnglish
Published United States 2022
Subjects
Animals
Cytopathogenic Effect, Viral
Dengue
Dengue Virus - immunology
Disease Models, Animal
Humans
Immunohistochemistry
Mice
Tissue
Mouse model
Immune response
Pathogenesis
Dengue
Humans
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Summary:The analysis of dengue virus (DENV) infected tissues in mice experimental model and in human biopsies/autopsies may support the pathogenesis studies. Through such models, it is possible to investigate possible histopathological changes caused by the infection and detections of different targets of interest, such as viral antigens, immune cells, and cytokines. In this chapter, we showed a brief review of how histological and immunohistochemistry approaches may improve the knowledge in this field.
ISSN:1940-6029
DOI:10.1007/978-1-0716-1879-0_18