Acitretin-induced acral hemorrhagic lesions in Darier-White disease

Darier-White disease (DD) is an autosomal-dominant inherited disease characterized by keratotic papules that are usually located in seborrheic areas. Systemic retinoids generally are first-line treatment in cases of diffuse DD. We report the case of an 84-year-old woman with a hypertrophic variant o...

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Bibliographic Details
Published inCutis (New York, N.Y.) Vol. 94; no. 6; p. E1
Main Authors Zavattaro, Elisa, Celasco, Melissa, Delrosso, Giorgio, Ferri, Simona, Bornacina, Carlo, Valente, Guido, Veronese, Federica, Fusco, Nicola, Gariglio, Marisa, Colombo, Enrico
Format Journal Article
LanguageEnglish
Published United States 01.12.2014
Subjects
Acitretin - administration & dosage
Acitretin - adverse effects
Aged, 80 and over
Darier Disease - drug therapy
Darier Disease - pathology
Female
Hemorrhage - etiology
Hemorrhage - pathology
Humans
Keratolytic Agents - administration & dosage
Keratolytic Agents - adverse effects
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Summary:Darier-White disease (DD) is an autosomal-dominant inherited disease characterized by keratotic papules that are usually located in seborrheic areas. Systemic retinoids generally are first-line treatment in cases of diffuse DD. We report the case of an 84-year-old woman with a hypertrophic variant of DD with acral lesions. Oral retinoids (acitretin) were administered as a first treatment of DD, with good clinical results. After a few months, hemorrhagic vesicles developed on palmoplantar surfaces. Suspension of the therapy led to the disappearance of the cutaneous manifestations.
ISSN:2326-6929