Vascular Calcification - Pathological Mechanism and Clinical Application - . Mechanisms of vascular calcification

Vascular calcification is an independent risk factor for the development of cardiovascular disease and is classified into two types based on the site of calcification : intimal atherosclerotic calcification and Mönckeberg's medial calcification. Matrix vesicles released from macrophages and vas...

Full description

Saved in:
Bibliographic Details
Published inClinical calcium Vol. 25; no. 5; p. 635
Main Author Shioi, Atsushi
Format Journal Article
LanguageJapanese
Published Japan 01.05.2015
Subjects
Animals
Apoptosis
Calcinosis
Cardiovascular Diseases - etiology
Cellular Senescence
Diphosphates - metabolism
Elastin - metabolism
Extracellular Matrix
Humans
Macrophages
Mice
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - metabolism
Muscle, Smooth, Vascular - pathology
Osteogenesis
Risk Factors
Vascular Calcification - classification
Vascular Calcification - etiology
Online AccessGet more information

Cover

More Information
Summary:Vascular calcification is an independent risk factor for the development of cardiovascular disease and is classified into two types based on the site of calcification : intimal atherosclerotic calcification and Mönckeberg's medial calcification. Matrix vesicles released from macrophages and vascular smooth muscle cells (VSMC) during apoptosis play a pivotal role in formation of fine granular calcification, while osteogenic differentiation of VSMC contributes to progression of advanced calcification. Recent noninvasive imaging studies of atherosclerotic calcification provide robust evidence that inflammation precedes active calcification, leading to establish the inflammation-dependent calcification paradigm. On the other hand, elastin degradation by increased elastolytic activities and disturbance of regulatory systems of extracellular pyrophosphate metabolism play an important role in development of Mönckeberg's medial calcification.
ISSN:0917-5857