Clinical associations of genetic variants of interleukins with the formation of chronic lympholeukemia in elderly patients

We investigated association of polymorphisms of interleukin IA (IL-1A), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin-8 (1L-8) genes in elderly patients with predisposition to the development of chronic lym,nphocytic leukemia (CLL). Risk factor of chronic lymphocytic leukemia is a genetic...

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Published inKlinicheskaia meditsina Vol. 91; no. 11; p. 47
Main Authors Sirotina, S S, Tikunova, T S, Proshchaev, K I, Efremova, O A, Churnosov, M I, Sirotin, A A, Evdokimov, V I, Poltoratskii, A N, Smagina, M V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2013
Subjects
Adult
Aged
Aged, 80 and over
Chronic Disease
Female
Genetic Variation - genetics
Humans
Interleukins - genetics
Leukemia, Lymphoid - genetics
Male
Middle Aged
Risk Factors
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Summary:We investigated association of polymorphisms of interleukin IA (IL-1A), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin-8 (1L-8) genes in elderly patients with predisposition to the development of chronic lym,nphocytic leukemia (CLL). Risk factor of chronic lymphocytic leukemia is a genetic variant -590T IL-4 (OR = 1,45) and protective factor -590S IL-4 (OR = 0,68). Genetic markers -590T IL-4 (OR = 2,46), -590TT IL-4 (OR = 6,65) and mix-590TT genotype of IL-4 allele 703S-IL-5 (OR = 6.70) were associated with stage 0-1 chronic lymphocytic leukemia whereas genetic markers -889T IL-1A (OR = 1,51), -703T IL-5 (OR = 1,52) and a combination of genotype -703ST IL-5 allele-251A IL-8 (OR = 2.85) were related to the development of stage II of the disease. Risk factor for the formation of II-IV stages of chronic lymphocytic leukemia is a genetic variant -703T IL-5 (OR = 1,95).
ISSN:0023-2149