Clinical Features and Prognosis of 35 Children with Burkitt Lymphoma/Leukemia

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 27; no. 4; p. 1123
• Main Authors: Zheng, Yong-Zhi, LE, Shao-Hua, Zheng, Hao, Hua, Xue-Ling, Chen, Zai-Sheng, Zheng, Ling, Chen, Cai, Li, Mei, Cai, Chun-Xia, Yang, Jing-Hui, Chen, Yi-Qiao, Gao, Qin-Li, Chen, Ying-Ying, Li, Jian, Hu, Jian-Da
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2019
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2019.04.021

To investigate the clinical features and prognostic factors of childhood Burkitt Lymphoma/leukemia. The clinical data of 35 patients with newly-diagnosed childhood Burkitt lymphoma/leukemia from March 2011 to September 2017 in Fujian Medical University Union Hospital were retrospectively analyzed and summarized. Among 35 patients, 5 gave up treatment and one patient died of multiple organ failure before treatment, and 29 patients received CCCG-BNHL-2010 protocol chemotherapy. The 35 cases of BL/L includsd 31 males and 4 females (M∶F=7.75∶1) with the median age of 5(2.0-11) years. Clinically, the common infiltration sites were as follows: abdominal organs (especially ileocecus, 21/35, 60%), bone marrow (21/35, 60%), faciomaxillary (10/35, 28.57%), and central nervous system (8/35, 22.85%). According to St. Jude staging system, 6 patients were grouped into stage Ⅱ, and 8 into stage Ⅲ and 21 into stage Ⅳ, among which the bone marrow blasts of 17 patients were more than 25%. The analysis of therapeutic efficacy a