EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS

• Published in: Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 78; no. 12; p. 6
• Main Authors: Popov, S S, Pashkov, A N, Shul'gin, K K
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2015
• Subjects: Aconitate Hydratase - blood; Adult; Aged; alpha-Tocopherol - agonists; alpha-Tocopherol - blood; Antioxidants - therapeutic use; Citric Acid - blood; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - pathology; Female; Humans; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Malondialdehyde - blood; Melatonin - therapeutic use; Middle Aged; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - pathology; Oxidative Stress - drug effects
• ISSN: 0869-2092
• DOI: 10.30906/0869-2092-2015-78-12-6-10

Type 2 diabetes mellitus complicated by steatohepatitis is accompanied by a decrease in aconitate hydratase activity, increase in the content of diene conjugates, decrease in the concentration of α-tocopherol, and change in the citrate level in the blood serum of patients, which is evidence of the development of oxidative stress as a result of the intensification of free radical oxidation of biosubstrates and decreasing degree of antioxidant defense of the organism. Combined therapy with melaxen provided a more significant change of the investigated parameters toward the norm (on the average by 36%, p 0.05) in comparison with basic treatment. This result was evidently associated with implementation of the antioxidant effect of melatonin, the level of which is corrected under the action of the drug employed.