Triglyceride (TG) and remnant lipoproteins

Lowering low-density lipoprotein (LDL) cholesterol (LDL-C) can reduce the risk of cardiovascular disease (CVD) by approximately 30%, and the remaining 70% should be the second front of CVD risk reduction. Such residual risks include high triglyceride (TG) concentrations and low levels of high-densit...

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Bibliographic Details
Published inRinsho byori. The Japanese journal of clinical pathology Vol. 60; no. 4; p. 343
Main Authors Yoshida, Hiroshi, Kisugi, Reiko, Koike, Masaru, Kurosawa, Hideo
Format Journal Article
LanguageJapanese
Published Japan 01.04.2012
Subjects
Biomarkers - blood
Cardiovascular Diseases - diagnosis
Humans
Lipoproteins - blood
Triglycerides - blood
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Summary:Lowering low-density lipoprotein (LDL) cholesterol (LDL-C) can reduce the risk of cardiovascular disease (CVD) by approximately 30%, and the remaining 70% should be the second front of CVD risk reduction. Such residual risks include high triglyceride (TG) concentrations and low levels of high-density lipoprotein (HDL) cholesterol (HDL-C) in terms of dyslipidemia. TG-rich lipoproteins are heterogenous and composed of a variety of subfractions, all of which are not necessarily relevant to atherosclerosis and CVD risk. However, remnant lipoproteins, TG-rich lipoproteins, are atherogenic and related to CVD risk. Two different methods (RLP-C and RemL-C) have been developed to measure cholesterol levels of remnant lipoproteins. Although there is a difference in affinity to intermediate-density lipoprotein (IDL) between the two methods, they may be better qualified as biomarkers of CVD risk than TG itself. TG measurements play a certain role in the evaluation of CVD risk, but the remnant lipoprotein cholesterol measurement can provide better screening for patients at high CVD risk than TG and may be a useful examination in both quantity and quality.
ISSN:0047-1860