ID4 gene polymorphism and osteoporosis in Thai menopausal women

The inhibitor of DNA binding 4 (ID4) protein regulates osteogenic and adipogenic cell fate and lack of lD4 gene expression decreased osteoblast differentiation. Variant in the ID4 gene polymorphism has not been reported with osteoporosis. To identify whether ID4 can be a marker gene for osteoporosis...

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Published inJournal of the Medical Association of Thailand Vol. 97; no. 10; p. 1004
Main Authors Chupeerach, Chaowanee, Kulanuwat, Sirikul, Chuenta, Wanida, Wannaiampikul, Sivaporn, Schuh, Vanessa Anne, Preutthipan, Sangchai, Tungtrongchitr, Rungsunn
Format Journal Article
LanguageEnglish
Published Thailand 01.10.2014
Subjects
3' Untranslated Regions - genetics
Adult
Aged
Asian Continental Ancestry Group
Bone Density - physiology
Female
Genotype
Humans
Inhibitor of Differentiation Proteins - genetics
Lumbar Vertebrae - physiology
Middle Aged
Osteoporosis, Postmenopausal - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Thailand
Thailand
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Summary:The inhibitor of DNA binding 4 (ID4) protein regulates osteogenic and adipogenic cell fate and lack of lD4 gene expression decreased osteoblast differentiation. Variant in the ID4 gene polymorphism has not been reported with osteoporosis. To identify whether ID4 can be a marker gene for osteoporosis in Thai menopausal women. The 3 'UTR of lD4 (rs3798339) single nucleotide polymorphism was examined bypolymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP), together with lumbar spine bone mineral density (BAMD) in 160 Thai menopausal women. Lumbar spine 3 (L3) had a significantly lower BMD score in women with the TT genotype, compared with the CT+CC genotypes (p = 0.037). This disappeared after the adjustment of various factors. The polymorphism at 3'UTR of lD4 gene can alter ID4 mRNA stability, and may be linked to the function of proteins. However, this needs confirmation in larger populations. The present study is useful as an initial investigation into ID4 gene polymorphism in osteoporosis.
ISSN:0125-2208