A Case of Pathological Complete Response for MSI-High Locally Advanced Unresectable Transverse Colon Cancer Treated with Nivolumab plus Ipilimumab Combination Therapy

74-year-old woman was diagnosed with locally advanced unresectable transverse colon cancer. She started CAPOX therapy as first-line therapy after ileostomy. After second course, MSI-high was detected, so nivolumab plus ipilimumab combination therapy was started as second-line therapy. After 4 course...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 50; no. 13; p. 1968
Main Authors Nishizawa, Yujiro, Kagawa, Yoshinori, Inoue, Akira, Ozato, Yuki, Kumode, Akinori, Ueda, Yuki, Takahashi, Megumi, Fukui, Akiko, Komatsu, Hisateru, Hirota, Masashi, Miyazaki, Yasuhiro, Tomokuni, Akira, Motoori, Masaaki, Iwase, Kazuhiro, Fujitani, Kazumasa
Format Journal Article
LanguageJapanese
Published Japan 01.12.2023
Subjects
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Colon, Transverse
Colonic Neoplasms - drug therapy
Colonic Neoplasms - surgery
Female
Humans
Ipilimumab
Nivolumab - therapeutic use
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Summary:74-year-old woman was diagnosed with locally advanced unresectable transverse colon cancer. She started CAPOX therapy as first-line therapy after ileostomy. After second course, MSI-high was detected, so nivolumab plus ipilimumab combination therapy was started as second-line therapy. After 4 courses of combination therapy, she was judged to be in partial response and surgery was performed. Histopathological diagnosis of the surgical specimen showed complete response, and she is still alive without recurrence 15 months after surgery.
ISSN:0385-0684