Comparation of gastrointestinal absorption studies of specnuezhenide with salidroside in rats

The experiment was designed to study the mechanism of increasing efficiency of Ligustrum lucidum steamed with wine. Rats in vivo with gastrointestinal perfusion model were used. The contents of salidroside and specnuezhenide in the fluid of gastrointestinal perfusion of rats were measured by HPLC at...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 39; no. 6; p. 1107
Main Authors Li, Hui-Fen, Zhang, Xue-Lan
Format Journal Article
LanguageChinese
Published China 01.03.2014
Subjects
Animals
Chemistry, Pharmaceutical
Gastrointestinal Tract - metabolism
Glucosides - chemistry
Glucosides - metabolism
Intestinal Absorption
Male
Phenols - chemistry
Pyrans - chemistry
Pyrans - metabolism
Rats
Rats, Sprague-Dawley
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Summary:The experiment was designed to study the mechanism of increasing efficiency of Ligustrum lucidum steamed with wine. Rats in vivo with gastrointestinal perfusion model were used. The contents of salidroside and specnuezhenide in the fluid of gastrointestinal perfusion of rats were measured by HPLC at different time points after dosing. Then the K(a) and absorption percentage were calculated. Specnuezhenide could be detected in the fluid of gastrointestinal perfusion of specnuezhenide. The K(a) of the specnuezhenide and salidroside in the fetal intestines are 0.055 3 and 0.144 2 h(-1) respectively and the total absorptivity are 24.46% and 60.14% respectively after 4 hours. The K(a) in the stomach are 5.70 and 8.26 h(-1) respectively and the total absorptivity are 34.21% and 47.23% respectively after 4 hours. The experiment proved that specnuezhenide can be metabolized into salidroside which is more beneficial for gastrointestinal absorption. The experiment proved that specnuezhenide can be metabolized into sali
ISSN:1001-5302
DOI:10.4268/cjcmm20140630