Effects of Lonicera Japonica flavone on immunomodulation in mice

To study immunomodulating activity of Lonicera Japonica flavone by investigating immune enzymatic activity of serum and antoxidized activity of lymphoid organs in mice. Fifty KM mice were randomly divided into control group, model group, low dose group, middle dose group and high dose group(n = 10),...

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Published inZhongguo ying yong sheng li xue za zhi Vol. 31; no. 1; p. 89
Main Authors Pi, Jian-hui, Tan, Juan, Hu, Zhao-tun, Xiang, De-biao
Format Journal Article
LanguageChinese
Published China 01.01.2015
Subjects
Acid Phosphatase - blood
Alkaline Phosphatase - blood
Animals
Antioxidants - metabolism
Flavones - pharmacology
Immunomodulation
Lonicera - chemistry
Malondialdehyde - metabolism
Mice
Monoamine Oxidase - metabolism
Muramidase - blood
Superoxide Dismutase - metabolism
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Summary:To study immunomodulating activity of Lonicera Japonica flavone by investigating immune enzymatic activity of serum and antoxidized activity of lymphoid organs in mice. Fifty KM mice were randomly divided into control group, model group, low dose group, middle dose group and high dose group(n = 10), respectively. And low dose group, middle dose group and high dose group were given Lonicera Japonica flavone with 100 mg/kg, 200 mg/kg and 400 mg/kg every day, respectively, while control group and model group were administered with NS. After continuously giving drug 7 weeks, other groups were injected with Dexamethasome (Dex: 25 mg /kg) for 3 days by subcutaneous injection, but the control group were treated with NS. And after giving Lonicera Japonica flavone 1 week simultaneously, organ indexes , the activity of acid phosphatase (ACP), alkaline phosphatase (AKP) and lysozyme (LSZ) in serum , and the content of monoamine oxidase (MAO), total antioxidant capacity (T-AOC), total superoxide dismutase (SOD) and malon
ISSN:1000-6834