Research progress on microRNA associated with chemoresistance of NHL

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 22; no. 5; p. 1490
• Main Authors: Zheng, Rong-Li, Jiang, Yu-Jie, Wang, Xin
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2014
• Subjects: Animals; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Lymphoma, Non-Hodgkin - drug therapy; Lymphoma, Non-Hodgkin - genetics; MicroRNAs - genetics
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2014.05.059

Non-Hodgkin's lymphoma (NHL) is a malignant tumor originated in lymphatic hematopoietic tissue. At present, chemotherapy is the main treatment method of NHL, but the chemoresistance is still an important reason for NHL treatment failure. The mechanism of NHL multidrug resistance (MDR) is complex, involving a variety of singnal pathways, in which mutation in the genetic level of the key genes can result in tumor cell resistance phenomenon. MicroRNA are small non-coding RNA that can be widely detected in plants,animal species and viruses. They regulate protein expression by repressing translation mRNA target at the post-transcriptional level, participating in the differentiation and development of tumor cells, as well as the occurrence and development of tumor, the change of the expression level microRNA plays an important role in the genesis and chemoresistance mechanism of NHL. Therefore, the intervening factitiously the expression level of microRNA in NHL through manufacturing antisense oligonucleotide (AMO)