Imbalance of Th17 and Treg cells in peripheral blood from multiple myeloma patients

• Published in: Zhōnghuá xuèyèxué zázhì Vol. 34; no. 11; p. 936
• Main Authors: Li, Jing-jing, Niu, Qian, Tang, Di-jiao, Jiang, Neng-gang, Jin, Yong-mei, Su, Jun, Jia, Yong-qian
• Format: Journal Article
• Language: Chinese
• Published: China 01.11.2013
• Subjects: Adult; Aged; Female; Flow Cytometry; Humans; Lymphocyte Count; Male; Middle Aged; Multiple Myeloma - immunology; Multiple Myeloma - pathology; T-Lymphocytes, Regulatory - cytology; Th17 Cells - cytology
• ISSN: 0253-2727
• DOI: 10.3760/cma.j.issn.0253-2727.2013.11.006

To investigate the ratio of Th17 cells and CD4⁺CD25⁺Foxp3⁺ regulatory T (Treg) cells in peripheral blood from patients with multiple myeloma (MM) and explore its pathological effects. 70 MM patients were divided into three groups: newly diagnosed group (n=30), plateau stage group (n=23) and relapsed/refractory group (n=17). The controls consisted of 20 healthy donors. The frequencies of Th17 and Treg cells were detected by flow cytometry. Compared with controls [(0.72±0.33)%] and plateau stage group [(0.74±0.29)%], frequencies of Th17 cells were higher in newly diagnosed group [(1.62±0.65)%] and relapsed/refractory group [(1.45±0.51)%], respectively (P<0.05). Compared with controls [(2.33±0.90)%] and plateau stage group [(1.69±0.70)%], frequencies of Treg cells were significantly lower in newly diagnosed group [(0.55±0.23)%] and relapsed/refractory group [(0.82±0.54)%], respectively (P<0.05). The ratios of Th17/Treg in newly diagnosed group and relapsed/refractory group were higher than those in controls (P<0