A Case of Type 4 Gastric Cancer with Esophageal Invasion That Responded to Neoadjuvant Chemotherapy Containing S-1 and Oxaliplatin followed by Surgery

We encountered a case of type 4 gastric cancer with esophageal invasion that responded to neoadjuvant chemotherapy containing S-1 and oxaliplatin(SOX)followed by surgery, which could be curative resection. A 46-year-old man was referred to our hospital because of abnormal upper gastrointestinal seri...

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Published inGan to kagaku ryoho Vol. 45; no. 13; p. 2327
Main Authors Hagino, Shigeta, Fujimura, Takashi, Kurata, Toru, Shoji, Yasuhiro, Sasaki, Shozo, Terada, Itsuro, Yoshikawa, Akemi, Kitagawa, Hirohisa, Izumi, Ryohei, Saito, Katsuhiko
Format Journal Article
LanguageJapanese
Published Japan 01.12.2018
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cisplatin
Drug Combinations
Esophagus - pathology
Gastrectomy
Humans
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Invasiveness
Oxaliplatin - administration & dosage
Oxonic Acid - administration & dosage
Oxonic Acid - therapeutic use
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Tegafur - administration & dosage
Tegafur - therapeutic use
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Summary:We encountered a case of type 4 gastric cancer with esophageal invasion that responded to neoadjuvant chemotherapy containing S-1 and oxaliplatin(SOX)followed by surgery, which could be curative resection. A 46-year-old man was referred to our hospital because of abnormal upper gastrointestinal series findings. He was diagnosed with type 4 advanced gastric cancer with esophageal invasion, cT4b(diaphragm)N2M0, Stage ⅢC, and 3 courses of neoadjuvant SOX therapy were administered. Adverse events were minor. After NAC, the primary lesion and lymph nodes showed marked reductions on CT; total gastrectomy and subtotal thoracic esophagectomy were performed. The pathological response to NAC was evaluated as Grade 2 in the primary tumor and Grade 3 in the lymph node; overall, NAC showed considerable antitumor effects. The final diagnosis was ypT3N0M0P0CY0H0, StageⅡA, and was judged as curatively resected. Currently, we are continuing to administer adjuvant chemotherapy containing S-1.
ISSN:0385-0684