Clinicopathologic features of gastrointestinal tract involvement of anaplastic large cell lymphoma

• Published in: Zhōngguó yīxué kēxuéyuàn xuébào Vol. 34; no. 3; p. 228
• Main Authors: Sun, Jian, Zhou, Jiao-lin, Chen, Jie, Lu, Chao-hui
• Format: Journal Article
• Language: Chinese; English
• Published: China 01.06.2012
• Subjects: Adult; Biomarkers, Tumor - metabolism; Epstein-Barr Virus Infections; Female; Gastrointestinal Neoplasms - diagnosis; Gastrointestinal Neoplasms - pathology; Gene Rearrangement, T-Lymphocyte; Humans; Ki-1 Antigen - metabolism; Lymphoma, Large-Cell, Anaplastic - diagnosis; Lymphoma, Large-Cell, Anaplastic - pathology; Male; Retrospective Studies
• ISSN: 1000-503X
• DOI: 10.3881/j.issn.1000-503X.2012.03.007

To investigate the clinicopathological characteristics of gastrointestinal tract involvement of anaplastic large cell lymphoma (ALCL). The clinicopathological features of four patients with ALCL that involved gastrointestinal tract were retrospectively analyzed using immunohistochemical study, T-cell receptor gene rearrangement analysis, and evaluation for Epstein Barr virus infection status. Most tumor cells in all these four cases are large and highly pleomorphic, and all four cases were classified as the common pattern ALCL. Tumor cells in all four tumors expressed CD30, and expressed at least one cytotoxic maker. Two patients were confirmed to be with anaplastic lymphoma kinase (ALK)-positive ALCL, and four patients were negative during in situ hybridization for Epstein-Barr virus-encoded RNA but showed clonal T-cell receptor gene rearrangement. Gastrointestinal tract involvement of ALCL has the unique clinicopathological features.