Research progress on therapeutic targets of active components in Chinese herbs for treatment of nonalcoholic fatty liver disease

• Published in: Zhongguo zhongyao zazhi Vol. 42; no. 6; p. 1109
• Main Authors: Pan, Yu-Ting, Xu, Fang-Yuan, Yu, Xi-Zhong, Shang, Wen-Bin
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2017
• Subjects: Adenylate Kinase - metabolism; Anti-Inflammatory Agents - pharmacology; Antioxidants - pharmacology; Drugs, Chinese Herbal - pharmacology; Humans; Insulin Resistance; Non-alcoholic Fatty Liver Disease - drug therapy; PPAR gamma - metabolism; Signal Transduction; nonalcoholic fatty liver disease; therapeutic targets; active components
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20170121.021

Nonalcoholic fatty liver disease(NAFLD) is a kind of metabolic liver injury, which is closely associated with insulin resistance and genetic susceptibility. Traditional Chinese herbs used in the treatment of nonalcoholic fatty liver disease are widely investigated in recent years. A series of recent studies show that the effects of the active components in traditional Chinese herbs on NAFLD are associated with activating AMPK signaling pathway, improving insulin resistance, modulating the activity and expression of peroxisome proliferator-activated receptor γ, antioxidant and anti-inflammatory activities and regulating intestinal flora. In this review, the potential therapeutic targets of the active components from traditional Chinese herbs for NAFLD would be summarized to provide a new thought for further research and clinical treatment of nonalcoholic fatty liver disease.