Effects of ulinastatin on cognitive function in patients with coronary artery bypass grafting

• Published in: Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban Vol. 44; no. 5; pp. 532 - 538
• Main Authors: Ge, Ya-li, Shi, Hong-wei, Zhu, Wen-fei, Ma, Zheng-Liang, Wei, Hai-yan, Gu, Xiao-ping, Bao, Hong-guang
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2015
• Subjects: Cognition - drug effects; Coronary Artery Bypass; Glycoproteins - therapeutic use; Humans; Inflammation - drug therapy; Interleukin-10 - blood; Interleukin-6 - blood; Postoperative Complications - prevention & control; S100 Calcium Binding Protein beta Subunit - blood; Tumor Necrosis Factor-alpha - blood
• ISSN: 1008-9292

To investigate the effects of ulinastatin(UTI) on postoperative cognitive function in patients undergoing coronary artery bypass grafting. One hundred and twenty-seven patients undergoing elective coronary artery bypass surgery were randomly divided into three groups:high-dose UTI group(16000 U/kg i.v.), low-dose UTI group(8000 U/kg i.v.) and control group(normal saline). The levels of plasma cortisol were measured before and one day after surgery. The level of IL-6, IL-10, TNF-α and S100β were measured before operation(T0), at open chest(T1), end of operation(T2), 6 h(T3)and 24 h(T4) after operation. A neuropsychological test scale was to evaluate the cognitive function 1 day before operation, 1 week and 3 months after operation. Ninety-three patients completed the study. There was no significant difference in general information of patients among three groups(P>0.05). The level of plasma cortisol one day after operation was significantly higher than that before operation in control group(P<0.01). The levels