Association of vitamin D receptor gene polymorphisms with Parkinson disease

• Published in: Zhonghua yi xue yi chuan xue za zhi Vol. 30; no. 1; p. 13
• Main Authors: Liu, Hong-xin, Han, Xun, Zheng, Xue-ping, Li, Yong-sheng, Xie, An-mu
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2013
• Subjects: Aged; Alleles; Base Sequence; Case-Control Studies; Female; Gene Frequency; Genetic Association Studies; Genotype; Humans; Male; Middle Aged; Parkinson Disease - genetics; Polymorphism, Genetic; Receptors, Calcitriol - genetics; Sex Factors
• ISSN: 1003-9406
• DOI: 10.3760/cma.j.issn.1003-9406.2013.01.004

Vitamin D receptor (VDR) has been proposed as a candidate gene for susceptibility to Parkinson's disease (PD). This study was set to assess the association between VDR gene Apa I and Taq I polymorphisms and PD in a Chinese Han population. Two hundred and eighty five sporadic PD patients and 285 healthy controls were genotyped for the Apa I and Taq I polymorphisms in VDR gene using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. No significant difference was detected in genotype or allele distribution of both Apa I and Taq I polymorphisms between PD patients and controls (P U+003E 0.05). No TT genotype for Taq I was found in the studied population. For Taq I, the distribution of genotype was significantly different between male PD patients and controls (U+03C7 2=4.187, P=0.032, OR=2.149, 95%CI: 1.011-4.567), and the frequency of T allele was significantly higher in male PD patients than male controls (U+03C7 2=3.867, P=0.036, OR=2.064, 95%CI: 0.989-4.307). VDR gene Apa I p