A case of recurrent gastric cancer successfully treated by a combination of CPT-11 and CDDP as the third-line chemotherapy

We report a case of recurrent gastric cancer successfully treated by a combination of CPT-11 and CDDP as the third- line chemotherapy. A 78-year-old man with advanced gastric cancer underwent a curative distal gastrectomy. Three years later, the tumor marker level began to rise and computed tomograp...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 39; no. 12; p. 2354
Main Authors Tonooka, Toru, Yoshioka, Shigeru, Wakatsuki, Kazuo, Kataoka, Masaaki, Miyazawa, Kotaro, Oeda, Yoshio
Format Journal Article
LanguageJapanese
Published Japan 01.11.2012
Subjects
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
Cisplatin - administration & dosage
Humans
Lymphatic Metastasis
Male
Recurrence
Salvage Therapy
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
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Summary:We report a case of recurrent gastric cancer successfully treated by a combination of CPT-11 and CDDP as the third- line chemotherapy. A 78-year-old man with advanced gastric cancer underwent a curative distal gastrectomy. Three years later, the tumor marker level began to rise and computed tomography (CT) revealed lymph node metastasis invading the pancreas resulting in pancreatic duct dilatation. S-1 treatment was initiated but was discontinued because of a systemic exanthem. Paclitaxel was administrated as secondary chemotherapy. But, after 2 courses, a further increase in the tumor marker level and portal vein invasion were observed. Combination therapy of CPT-11 and CDDP was administered as the third-line chemotherapy. After 3 courses, the tumor marker level normalized, tumor size decreased, and the invasion was eliminated. Third-line chemotherapy against recurrent gastric cancer should be considered if patient performance status (PS) is maintained.
ISSN:0385-0684