Clinical Characteristics and Treatment Efficacy of Children with SIL/TAL1 Positive T-Cell Acute Lymphoblastic Leukemia

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 24; no. 3; p. 681
• Main Authors: Liu, Xiao, Li, Wei-Jing, Zhao, Xiao-Xi, Gao, Chao, Zhao, Wei, Jiang, Jin, Zhang, Rui-Dong, Xie, Jing, Shi, Hui-Wen, Wang, Bin, Zhang, Yong-Hong, Ma, Xiao-Li, Zhou, Xuan, Wu, Min-Yuan, Cui, Lei, Li, Zhi-Gang
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2016
• Subjects: Antineoplastic Combined Chemotherapy Protocols; Child; Disease-Free Survival; Humans; Neoplasm, Residual - pathology; Oncogene Proteins, Fusion - genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Prognosis; Recurrence; Treatment Outcome
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2016.03.008

To investigate the clinical features, treatment and prognosis of children with SIL-TAL1 fusion gene positive T-cell acute lymphoblastic leukemia (T-ALL). The data of 101 children with T-ALL were collected from April 2005 to November 2012 in Beijing Children's Hospital. The common clinical features, early treatment response, minimal residual disease (MRD), event-free survival (EFS) and relapse-free survival (RFS) were compared between children with SIL-TAL1 positive and negative T-ALL. The treatment efficacy in children with SIL-TAL1 positive T-ALL was compared between BCH-2003 and CCLG-2008 protocol. Out of 101 cases, 22 cases (21.9%) of T-ALL carried SIL-TAL1 fusion gene. The distribution of sex, age, response to prednisone and central nervous system (CNS) involvement were no significant different at diagnosis between SIL-TAL1 positive and negetive patients. However, the WBC count in SIL-TAL1 positive cases were significantly higher than that of SIL-TAL1 negative cases at diagnosis (P<0.05). Additionally, MR