Clinical and pathogenetic significance of collagen metabolism disorder in children with gastroesophageal reflux disease

• Published in: Ėksperimental'nai͡a︡ i klinicheskai͡a︡ gastroėnterologii͡a no. 1; p. 20
• Main Authors: Butorina, N V, Zaprudnov, A M, Vakhrushev, Ia M, Sharaev, P N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2013
• Subjects: Adolescent; Antibodies, Bacterial - blood; Biopolymers - metabolism; Case-Control Studies; Child; Collagen - metabolism; Endoscopy, Digestive System; Feeding Behavior; Female; Gastric Juice - chemistry; Gastroesophageal Reflux - complications; Gastroesophageal Reflux - etiology; Gastroesophageal Reflux - metabolism; Gastroesophageal Reflux - microbiology; Helicobacter Infections - complications; Helicobacter Infections - etiology; Helicobacter Infections - metabolism; Helicobacter Infections - microbiology; Helicobacter pylori - immunology; Helicobacter pylori - isolation & purification; Humans; Male; Sialic Acids - metabolism
• ISSN: 1682-8658

In 62 children with gastroesophageal reflux disease (GERD) and 32 with gastroduodenitis (DG) aged 9-17 years, the peculiarities of metabolism of collagen were studied. High levels of fractions of sialic acids were set, that was associated with the protein fructose, fractions of hydroxyproline in children with GERD compared with the patients with DG, which testify to the process of degradation of collagen and may be one of the factors contributing to the local inflammation of the esophagus and gastroduodenal zone of the digestive tract. The prevalence of Helicobacter pylori, as well as violations of diet, play an important role in maintaining the inflammatory process.