Analysis on drug sensitivity spectrum of 167 multidrug-resistant Mycobacterium tuberculosis in China

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 41; no. 5; p. 764
• Main Authors: Chen, R, Li, M C, Zhao, L L, Zhao, X Q, Liu, H C, Liu, Z G, Lu, Y, Deng, Y L, Chen, Z X, Wan, K L, Yuan, X Q
• Format: Journal Article
• Language: Chinese
• Published: China 10.05.2020
• Subjects: Genotype; Multidrug-resistant tuberculosis; Cross resistance; Drug sensitivity test
• ISSN: 0254-6450
• DOI: 10.3760/cma.j.cn112338-20191121-00823

To investigate the drugs-sensitivity spectrum of multidrug-resistant tuberculosis (MDR-TB) in China and provide a scientific evidence for the drug selection in clinical therapy and the control of MDR-TB. A total of 167 strains of MDR-TB were included in this study. Every strain was genotyped by gene sequencing and their sensitivity to 13 different anti-TB drugs was tested by using MicroDST(TM) and BACTEC(TM) MGIT 960(TM) liquid-culturing method. The association between drug resistance and genotypes as well as cross drug resistance was also analyzed. The results were analyzed by means of the comparison of enumeration data between two groups with (2) test. The overall resistance rate of 167 MDR-TB strains to 11 anti-TB drugs, except isoniazide and rifampicin, was 95.81%, the rates of pre-extensive drug-resistance (pre-XDR) and extensive drug-resistance were 31.14%(52/167) and 6.59% (11/167), respectively. The streptomycin resistance rate of Beijing genotypes was significantly higher than that of the non-Beijing