Influence of artificial insemination with donor sperm on the pregnancy outcomes and safety of the offspring

To investigate the factors influencing the pregnancy outcomes of artificial insemination with donor sperm (AID), improve the pregnancy rate, and evaluate the safety of the offspring. We retrospectively analyzed 7,761 cycles of AID for 5,109 infertile couples performed between July 1, 2005 and June 3...

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Bibliographic Details
Published inZhonghua nan ke xue Vol. 22; no. 3; p. 229
Main Authors Liu, Ying, Liu, Xin-yu, Wang, Bing-song, Wang, Bao-sheng, Xu, Cheng-sheng, Li, Hui
Format Journal Article
LanguageChinese
Published China 01.03.2016
Subjects
Adult
Cryopreservation
Female
Humans
Infertility
Insemination, Artificial, Heterologous - methods
Male
Maternal Age
Ovulation Induction
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Retrospective Studies
Semen Preservation - methods
Spermatozoa
Time Factors
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Summary:To investigate the factors influencing the pregnancy outcomes of artificial insemination with donor sperm (AID), improve the pregnancy rate, and evaluate the safety of the offspring. We retrospectively analyzed 7,761 cycles of AID for 5,109 infertile couples performed between July 1, 2005 and June 30, 2013 in the Center of Reproductive Medicine of Shenyang No 204 Hospital, the outcomes of pregnancy, and the incidence of birth defects. Totally, 2 252 clinical pregnancies were achieved by AID, in which the pregnancy rate per cycle was 29. 02% and the cumulative pregnancy rate was 44. 08%. The clinical pregnancy rate was remarkably higher in the females of ≤ 35 years than in those of > 35 years old (30.31% vs 20.18%, P < 0.01), in the women with < 5-year infertility than in those with > 5-year infertility (30.83% vs 28.16%, P < 0.01), and in the patients of the ovarian stimulation group than in those of the natural cycle group (33.22% vs 28.68%, P < 0.01) The clinical pregnancy rate was the highest in the first
ISSN:1009-3591