A new bibenzyl derivative from stems of Dendrobium officinale

Eleven compounds were isolated from the 95% ethanol extract of the stems of Dendrobium officinale after water extraction by various modern chromatographic techniques, such as silica gel column chromatography(CC), octadecyl-silica(ODS) CC, Sephadex LH-20 CC, preparative thin layer chromatography(PTLC...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 48; no. 3; p. 700
Main Authors Meng, Wei-Tong, Meng, Xiao, Niu, Li-Ting, Zhang, Si-Si, Ouyang, Chun-Jie, Ding, Chun-Hua, Zhu, Ling-Juan, Zhang, Xue
Format Journal Article
LanguageChinese
Published China 01.02.2023
Subjects
Bibenzyls
Biological Assay
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Dendrobium
Dendrobium officinale
hypoglycemic activity
chemical constituents
structure elucidation
antioxidant activity
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Summary:Eleven compounds were isolated from the 95% ethanol extract of the stems of Dendrobium officinale after water extraction by various modern chromatographic techniques, such as silica gel column chromatography(CC), octadecyl-silica(ODS) CC, Sephadex LH-20 CC, preparative thin layer chromatography(PTLC) and preparative high performance liquid chromatography(PHPLC). According to spectroscopic analyses(MS, 1D-NMR, 2D-NMR) combined with optical rotation data and calculated electronic circular dichroism(ECD), their structures were identified as dendrocandin Y(1), 4,4'-dihydroxybibenzyl(2), 3-hydroxy-4',5-dimethoxybibenzyl(3), 3,3'-dihydroxy-5-methoxybibenzyl(4), 3-hydroxy-3',4',5-trimethoxybibenzyl(5), crepidatin(6), alternariol(7), 4-hydroxy-3-methoxypropiophenone(8), 3-hydroxy-4,5-dimethoxypropiophenone(9), auriculatum A(10) and hyperalcohol(11). Among them, compound 1 was a new bibenzyl derivative; compounds 2 and 7-11 have not been previously reported from Dendrobium plants; compound 6 was reported from D.offici
ISSN:1001-5302
DOI:10.19540/j.cnki.cjcmm.20220517.201