A Case of Pancreatic Mixed Acinar-Neuroendocrine Carcinoma with Main Pancreatic Duct Development

A 78-year-old man was referred to our hospital owing to a pancreatic tumor detected on ultrasonography. He showed weight loss, and his diabetes mellitus had worsened over 3 months. Abdominal contrast-enhanced computed tomography revealed a 3 cm diameter pancreatic head tumor with peripheral enhancem...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 46; no. 13; p. 2060
Main Authors Nomoto, Mayuko, Kusashio, Kimihiko, Yasutomi, Jun, Matsumoto, Masanari, Suzuki, Takeshi, Iida, Ayako, Fushimi, Kouya, Furukawa, Arata, Konishi, Takanori, Imamura, Namiko, Harano, Rina, Fujita, Akihiro, Koguchi, Hazuki, Udagawa, Ikuo, Ozaki, Daisuke
Format Journal Article
LanguageJapanese
Published Japan 01.12.2019
Subjects
Aged
Carcinoma, Neuroendocrine
Humans
Male
Neoplasm Recurrence, Local
Pancreatic Ducts
Pancreatic Neoplasms
Pancreaticoduodenectomy
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Summary:A 78-year-old man was referred to our hospital owing to a pancreatic tumor detected on ultrasonography. He showed weight loss, and his diabetes mellitus had worsened over 3 months. Abdominal contrast-enhanced computed tomography revealed a 3 cm diameter pancreatic head tumor with peripheral enhancement and a dilated pancreatic duct. He underwent subtotal stomach-preserving pancreaticoduodenectomy. Examination of intraoperative frozen sections did not indicate cancer involvement at the edge of the resected pancreatic duct. The tumor was histologically diagnosed as mixed acinar-neuroendocrine carcinoma(MANEC). It was mainly detected in the pancreatic head and was accompanied by intra-ductal growth in the pancreatic duct. The patient has survived for 21 months without recurrence. MANEC is a rare disease associated with intraductal growth. Intraoperative diagnosis of tumor involvement at the edge of the pancreatic duct may be useful for R0 resection in surgery for MANEC.
ISSN:0385-0684