Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population

• Published in: Zhonghua yi xue yi chuan xue za zhi Vol. 35; no. 2; p. 215
• Main Authors: Si, Peiru, Liu, Shulian, Tong, Dongxiao, Cheng, Meijin, Wang, Liwen, Cheng, Xiaoli
• Format: Journal Article
• Language: Chinese
• Published: China 10.04.2018
• ISSN: 1003-9406
• DOI: 10.3760/cma.j.issn.1003-9406.2018.02.015

To assess the association of polymorphisms of N-acyl-phosphatidylethanolamine-phospholipase D (DAPE-PLD) and fatty acid amide hydrolase (FAAH) genes, as well as their interaction, with schizophrenia. Polymorphisms of NAPE-PLD rs12540583 and FAAH rs324420, rs2295633, and rs6429600 were determined with PCR - restriction fragment length polymorphism assay and Sanger sequencing. The genotypes of 345 subjects of Han Chinese origin diagnosed with schizophrenia and a 403 controls were compared. The results were analyzed with SPSS 17.0, and the interaction of the two genes was analyzed using a multifactor dimensionality reduction (MDR) method. The frequency of NAPE-PLD rs12540583 polymorphism was significantly different between the two groups under both dominant and additive models (χ2=17.18 vs. χ2=18.94, P<0.0125). The frequencies of AC genotype and C allele of the patient group at rs12540583 were higher than those of the controls, and the interaction of NAPE-PLD and FAAH was associated with schizophrenia. A four-lo