Retrospective analysis of the Gram-positive bacteria-infected cases in the Department of Hematology

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 21; no. 5; p. 1291
• Main Authors: Jing, Yu, Bo, Jian, Zhao, Yu, Li, Hong-Hua, Wang, Shu-Hong, Huang, Wen-Rong, Wang, Quan-Shun
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2013
• Subjects: Acetamides - adverse effects; Acetamides - therapeutic use; Adult; Aged; Female; Gram-Positive Bacterial Infections - diagnosis; Gram-Positive Bacterial Infections - drug therapy; Humans; Linezolid; Male; Middle Aged; Oxazolidinones - adverse effects; Oxazolidinones - therapeutic use; Retrospective Studies; Teicoplanin - adverse effects; Teicoplanin - therapeutic use; Vancomycin - adverse effects; Vancomycin - therapeutic use
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2013.05.041

This study was purposed to evaluate the efficacy and safety of linezolid, vancomycin and teicoplanin for the treatment of patients infected by Gram-positive bacteria in the Department of Hematology by retrospective analysis. The patients with fever in our department from January to December in 2011 were selected for blood culture with Gram-positive bacteria and treated with linezolid, vancomycin or teicoplanin alone.Various parameters were recorded before and after treatment, such as fever time, respiratory symptoms, physical signs, radiographic changes, blood and biochemical routine, and adverse reactions. The efficacy and safety of linezolid, vancomycin and teicoplanin were compared according to the fever abating time, bacterial clearance rate, clinical efficiencies and adverse events. The patients were divided into linezolid group (15 patients), vancomycin group (17 patients) and teicoplanin group (20 patients). The results showed that the mean time of fever abating in linezolid group was (4.43 ± 3.15)d, b