Current concept of insulin therapy intensification, and the role of human regular insulin and rapid-acting insulin analogs in insulin treatment

The evolution of insulin therapy from animal insulin to recombinant human regular insulin has improved diabetes treatment. Generating of rapid-acting insulin analogs, mimicking physiologic insulin action enables us to provide better control of post-prandial glucose level and lower incidence of hypog...

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Bibliographic Details
Published inNihon rinshō Vol. 73; no. 3; p. 447
Main Authors Hamaguchi, Tomoya, Sadahiro, Katsuhiko, Satoh, Tomomi
Format Journal Article
LanguageJapanese
Published Japan 01.03.2015
Subjects
Female
Humans
Insulin Aspart - therapeutic use
Insulin Lispro - therapeutic use
Insulin, Short-Acting - administration & dosage
Insulin, Short-Acting - therapeutic use
Pregnancy
Pregnancy in Diabetics - drug therapy
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Summary:The evolution of insulin therapy from animal insulin to recombinant human regular insulin has improved diabetes treatment. Generating of rapid-acting insulin analogs, mimicking physiologic insulin action enables us to provide better control of post-prandial glucose level and lower incidence of hypoglycemia compared with human regular insulin. These rapid-acting insulin analogs show lower susceptibility of insulin precipitation and catheter occlusions, and are suitable for insulin pump therapy of continuous subcutaneous insulin infusion. Insulin lispro and insulin aspart are also applicable for diabetic patients with pregnancy, requiring excellent glycemic control. In some studies, stepwise addition of prandial insulin, as well as full basal-bolus regimen can improve glycemic control with less hypoglycemia. Treatment intensification with rapid-acting insulin analogs may offer a proper method to reach glycemic goals.
ISSN:0047-1852