Effect of single nucleotide polymorphisms of RS1826690 located in UGT2B4 gene on the pathological complete response to neoadjuvant chemotherapy in breast cancer patients

• Published in: Zhong hua yi xue za zhi Vol. 98; no. 16; p. 1242
• Main Authors: Gao, Q L, Zhang, X F, Geng, L, Tian, T D, Sun, X F
• Format: Journal Article
• Language: Chinese
• Published: China 24.04.2018
• Subjects: Neoadjuvant chemotherapy; Pathologic complete response; UGT2B4; Breast cancer; Single nucleotide polymorphisms
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2018.16.011

To evaluate the association between single nucleotide polymorphisms (SNPs) of RS1826690 located in UGT2B4 gene and pathological complete response (pCR) to neoadjuvant chemotherapy in breast cancer patients. A total of 146 breast cancer patients were enrolled to detect the SNPs of RS1826690 by sequenom. The relationship between SNPs of RS1826690 and pCR, predictors of pCR were analyzed by univariate or multivariate analysis. The frequency of CC, CT and TT genetype of RS1826690 was 20.6%, 39.7% and 39.7%, respectively. Of the 171 patients, pCR was achieved in 39 cases (26.7%), with CC allele in 14 cases, CT allele in 7 cases and TT allele in 18 cases, and statistically significant difference was observed (χ(2)=16.684, =0.003). Multivariate logistic regression analysis showed that SNPs of RS1826690 was an independent predictor of pCR (95% 2.311-28.810, =0.001) . SNPs of RS1826690 was statistically associated with estrogen receptor (ER) status (χ(2)=7.872, =0.020). SNPs of RS1826690 was associated with pCR, and b