Nagelamide I and 2,2'-didebromonagelamide B, new dimeric bromopyrrole-imidazole alkaloids from a marine sponge Agelas sp

• Published in: Chemical & pharmaceutical bulletin Vol. 62; no. 2; p. 213
• Main Authors: Iwai, Takahiro, Kubota, Takaaki, Fromont, Jane, Kobayashi, Jun'ichi
• Format: Journal Article
• Language: English
• Published: Japan 2014
• Subjects: Agelas - chemistry; Alkaloids - chemistry; Alkaloids - isolation & purification; Animals; Halogenation; Imidazoles - chemistry; Imidazoles - isolation & purification; Pyrroles - chemistry; Pyrroles - isolation & purification

New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2'-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric...