Nagelamide I and 2,2'-didebromonagelamide B, new dimeric bromopyrrole-imidazole alkaloids from a marine sponge Agelas sp

New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2'-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric...

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Published inChemical & pharmaceutical bulletin Vol. 62; no. 2; p. 213
Main Authors Iwai, Takahiro, Kubota, Takaaki, Fromont, Jane, Kobayashi, Jun'ichi
Format Journal Article
LanguageEnglish
Published Japan 2014
Subjects
Agelas - chemistry
Alkaloids - chemistry
Alkaloids - isolation & purification
Animals
Halogenation
Imidazoles - chemistry
Imidazoles - isolation & purification
Pyrroles - chemistry
Pyrroles - isolation & purification
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Summary:New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2'-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric bromopyrrole-imidazole alkaloid consisting of two subunits connected with a single bond.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1347-5223
1347-5223
DOI:10.1248/cpb.c13-00821