Analysis of Gene Mutation and Clinical Characteristics in 19 Children with Juvenile Myelomonocytic Leukemia

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 28; no. 6; p. 1811
• Main Authors: Weng, Kai-Zhi, Zheng, Yong-Zhi, Zhuang, Shu-Quan, Chen, Hai-Yun, LE, Shao-Hua
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2020
• Subjects: Child; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Leukemia, Myelomonocytic, Juvenile - genetics; Male; Mutation; Prognosis; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics; ras Proteins - genetics; Retrospective Studies
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2020.06.004

To analyze the gene mutations of children with juvenile myelomonocytic leukemia (JMML) and their correlation with clinical characteristics. The genetic mutation results and clinical data of 19 children with JMML in Fujian from January 2015 to December 2018 were collected and analyzed retrospectively. According to the results of gene mutation, they were divided into PTPN11 gene mutation group and non-PTPN11 gene mutation group, and the clinical characteristics and prognosis of children with JMML between two groups were compared. Among the 19 children with JMML, 14 cases were male and 5 cases were female, and male/female ratio was 2.8∶1. The median age at diagnosis was 13(3-48) months, and 14 cases (73.68%) were less than 2 years old. Abdominal distension and pyrexia were the common initial symptoms, and all the children with JMML had splenomegaly. The median white blood cell count was 39.82(4.53-103.4)×10 /L，and monocyte count was 4.37(1.04-23.12)×10 /L. HbF was higher than the normal high value of the same ag