Expressions of Snail, Slug and KAI1 proteins in cervical carcinoma and their clinicopathological significance

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 35; no. 12; p. 1733
• Main Authors: Gong, Xiaomeng, Tao, Yisheng, Zhou, Lei, Yu, Lan, Wu, Shiwu, Song, Wenqing, Wang, Danna, Cheng, Zenong
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2015
• Subjects: Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cervical Intraepithelial Neoplasia - metabolism; Cervical Intraepithelial Neoplasia - pathology; Female; Humans; Immunohistochemistry; Kangai-1 Protein - metabolism; Kaplan-Meier Estimate; Lymphatic Metastasis; Neoplasm Staging; Prognosis; Snail Family Transcription Factors; Survival Rate; Transcription Factors - metabolism; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology
• ISSN: 1673-4254

To explore the expression of Snail and Slug in primary cervical squamous cell carcinoma (CSCC) and their relationship with KAI1 expression. The expressions of Snail, Slug, and KAI1 proteins were examined by immunohistochemistry in 154 specimens of CSCC tissues, 50 specimens of cervical intraepithelial neoplasm (CIN), and 40 specimens of normal cervical tissues. The positivity rates of Snail, Slug, and KAI1 expression were 0%, 2.5%, and 95.0% in normal cervical tissues, 32.0%, 34.0% and 64.0% in CIN tissues, and 66.2%, 66.9%, and 43.5% in CSCC tissues, respectively, showing significant differences in the rates among the 3 groups (P<0.05). The expressions of Snail, Slug, and KAI1 were significantly correlated with the histological grades of the tumor, depth of invasion, lymph node metastasis, International Federation of Gynecology and Obstetrics (FIGO) stages, and postoperative survival time (P<0.05). The expressions of Snail and Slug were positively correlated (r=0.752, P<0.001), and both of them were negative