Study on acute HIV-1 infection in men who have sex with men in Tianjin

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 39; no. 11; p. 1472
• Main Authors: Ning, T L, Zheng, M N, Li, L, Bai, J Y, Zhao, X, Guo, Y, Du, X R, Cheng, S H
• Format: Journal Article
• Language: Chinese
• Published: China 10.11.2018
• Subjects: Adult; Asian Continental Ancestry Group; HIV Infections - diagnosis; HIV Infections - epidemiology; HIV-1; Homosexuality, Male; Humans; Male; Mass Screening - methods; Nucleic Acid Amplification Techniques; Viral Load; HIV-1; Acute infection; Men who have sex with men
• ISSN: 0254-6450
• DOI: 10.3760/cma.j.issn.0254-6450.2018.11.010

To understand the immunological and virological characteristics of HIV-1 infected men who have sex with men (MSM) in the acute phase in Tianjin and evaluate the effects of the fourth generation HIV ELISA and the P24 ELISA for acute HIV-1 infected samples. From October 2015 to October 2016, MSM were recruited through the community-based organizations in Tianjin. All the participants received rapid HIV test, positive samples were confirmed by Western Blot and negative samples underwent pooled nucleic acid testing. The participants with HIV-1 RNA reactive result underwent testing for viral load and T-cell count after second blood collection. Acute HIV-1 infection was defined as negative rapid HIV test result and the positive results of two HIV RNA tests, then the sensitivity were compared between the fourth generation HIV ELISA and the P24 ELISA to detect the initial HIV-1 RNA positive samples. Among 3 016 MSM screened, 193 were positive in rapid HIV test. Western blot testing indicated that 179 cases were HIV p