Efficacy of sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months: a systematic review
To investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months. Related databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3. A t...
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Published in | Zhongguo dang dai er ke za zhi Vol. 18; no. 6; p. 534 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
01.06.2016
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Subjects | |
Online Access | Get full text |
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Summary: | To investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months.
Related databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3.
A total of 20 RCTs involving 2 376 infants were included, and quality assessment showed that 6 RCTs had grade A quality and 14 had grade B quality. The Meta analysis showed that compared with sterile water, 25%-75% oral sweet solution significantly reduced crying time (WMD=-21.16, 95%CI -39.66 to -2.77, P<0.05) and the proportion of crying time (the duration of crying /3-minute periods after the injection) (WMD=-13.83, 95%CI -20.88 to -6.78, P<0.01), while the crying time showed no significant difference between the group treated with oral administration of 12% sucrose solution and non-intervention group. Co
Oral sweet solution (25%-75%; 2 mL) given 2 minutes before vaccination can effectively relieve the pain caused |
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ISSN: | 1008-8830 |
DOI: | 10.7499/j.issn.1008-8830.2016.06.013 |