A Case of Long-Term Survival after Surgeries for Gastric Cancer and Metachronous Ovarian Metastasis

• Published in: Gan to kagaku ryoho Vol. 42; no. 12; p. 2006
• Main Authors: Yoshida, Tatsuya, Wajima, Naoki, Akasaka, Harue, Sakuraba, Shingo, Muroya, Takahiro, Kubo, Norihito, Okano, Kensuke, Uchida, Chiaki, Hakamada, Kenichi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.2015
• Subjects: Antineoplastic Agents, Phytogenic - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cisplatin - administration & dosage; Drug Combinations; Female; Gastrectomy; Humans; Middle Aged; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - secondary; Ovarian Neoplasms - surgery; Ovariectomy; Oxonic Acid - administration & dosage; Paclitaxel - therapeutic use; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Tegafur - administration & dosage; Time Factors
• ISSN: 0385-0684

The patient was a 57-year-old woman. In October 2011, she underwent distal gastrectomy, D2 lymphadenectomy, and Roux-en-Y reconstruction for gastric cancer (pT4a, pN3b, Stage ⅢC [JCGC 14th Edition]). She then received S-1 plus CDDP combination therapy and S-1 monotherapy as postoperative adjuvant chemotherapies for 1 year, and was followed up as an outpatient. In April 2013, a significant increase in the CA19-9 level was noted, and CT indicated a right ovarian tumor. Ovarian metastasis from the gastric cancer was diagnosed, and the response to 3 courses of weekly PTX was stable disease. No findings indicated metastasis to other organs. In July 2013, a salpingo-oophorectomy was performed, after which her CA19-9 level returned to the normal range. Follow-up was adopted as the postoperative strategy in part due to the desires of the patient. Presently, 3 years and 6 months after the initial surgery and 1 year and 9 months after the last surgery, no recurrence has been detected. Generally, ovarian metastasis from gastric cancer is considered to be associated with a poor prognosis. However, our patient showed long-term survival after surgeries for gastric cancer and asynchronous ovarian metastasis. Here, we report the details of our case and review the relevant literature.