Autologous peripheral blood CD34+ stem cells transplanted into 100 patients with advanced cirrhosis

• Published in: Zhonghua gan zang bing za zhi Vol. 22; no. 9; p. 667
• Main Authors: Yao, Yutong, Luo, Lanyun, Xue, Hua, Luo, Le, Zou, Haibo, Wang, Guan, An, Zhiming, Zhong, Ming, Huang, Xiaobing, Zhu, Yifan, Wei, Lingling, Yang, Maozhu, Zhang, Tian, Xie, Ping, Xu, Gang, Deng, Shaoping, Huang, Xiaolun
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2014
• Subjects: Ascites; Humans; Liver Cirrhosis - therapy; Quality of Life; Stem Cell Transplantation; Transplantation, Autologous; Treatment Outcome
• ISSN: 1007-3418
• DOI: 10.3760/cma.j.issn.1007-3418.2014.09.007

To investigate whether transplantation of autologous peripheral blood CD34+ stem cells is a viable approach for treating patients with advanced cirrhosis,which is currently hindered by a shortage in liver donors. A total of 100 patients with advanced cirrhosis and who had failed to respond to conservative therapy were recruited for transplantation of autologous peripheral blood CD34+ stem cells.The success of transplantation was investigated 6-and 12-months later by measuring markers of liver biosynthesis function (coagulation,albumin level,indocyanine green clearance,Child-Pugh score) and assessing pathological changes (Knodell score) and morphologic changes in the liver tissue.Complications were also recorded during follow-up. The 1-year cumulative survival rate was 100%. Fifty-two patients with massive ascites showed gradual reduction and disappearance of the ascites.Four patients experienced upper gastrointestinal bleeding and three patients developed with hepatic encephalopathy (I-II degree) at 3 months