The Role of Oxytocin in Social Circuits and Social Behavior in Dementia

Administration of intranasal oxytocin has been found to improve social cognition in a number of brain conditions, including autism spectrum disorder and schizophrenia. Whether this approach is relevant in dementias is currently unknown, particularly in frontotemporal dementia, a younger-onset dement...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2384; p. 67
Main Authors Piguet, Olivier, Ahmed, Rebekah M, Kumfor, Fiona
Format Journal Article
LanguageEnglish
Published United States 2022
Subjects
Autism Spectrum Disorder
Frontotemporal Dementia
Humans
Neuropsychological Tests
Oxytocin
Social Behavior
Neuroimaging
Semantic dementia
Progressive nonfluent aphasia
Emotion procession
Alzheimer’s disease
Empathy
Hypothalamus
Frontotemporal dementia
Social cognition
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Summary:Administration of intranasal oxytocin has been found to improve social cognition in a number of brain conditions, including autism spectrum disorder and schizophrenia. Whether this approach is relevant in dementias is currently unknown, particularly in frontotemporal dementia, a younger-onset dementia characterized clinically by marked changes in social cognition and behavior and focal atrophy of the frontal and temporal lobes. This chapter provides an overview of the deficits in social cognition in frontotemporal dementia and reviews the emerging evidence of intranasal oxytocin administration as a potential treatment option for these deficits. Future research directions will also be discussed.
ISSN:1940-6029
DOI:10.1007/978-1-0716-1759-5_5