Prognostic value of procalcitonin, endotoxin and common inflammatory markers combining MELD score in patients with chronic severe hepatitis

• Published in: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 38; no. 4; p. 388
• Main Authors: Zhou, Qing, Tan, Deming, Yi, Zhaoquan, Zheng, Yixiang, Lu, Menghou
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2013
• Subjects: Adult; Age Factors; C-Reactive Protein - metabolism; Calcitonin - blood; Calcitonin Gene-Related Peptide; End Stage Liver Disease - diagnosis; End Stage Liver Disease - mortality; Endotoxins - blood; Female; Hepatitis, Chronic - diagnosis; Hepatitis, Chronic - mortality; Humans; Male; Middle Aged; Predictive Value of Tests; Prognosis; Protein Precursors - blood; ROC Curve; Severity of Illness Index; Survival Analysis
• ISSN: 1672-7347
• DOI: 10.3969/j.issn.1672-7347.2013.04.009

To evaluate the mid-term prognostic value of procalcitonin (PCT), endotoxin and common inflammatory markers combining the model for end-stage liver disease (MELD) score in patients with chronic severe hepatitis. A total of 124 chronic severe hepatitis patients were enrolled, who were hospitalized in the Department of Infectious Diseases, Xiangya Hospital, Central South University from May 2011 to December 2011. Indexes of inflammation, liver and kidney function tests and MELD were determined within 24 h after the admission, and blood samples were collected for measurement of endotoxin , procalcitonin (PCT), and C-reactin protein (CRP). The outcome was confirmed after discharge follow-up at the end of the 3rd month. According to the outcome, the 124 patients were divided into a survival group (n=58) and a death group(n=66). 1) Of the 124 patients, 66 died and 58 survived, with statistical difference in age, MELD score, white blood cell (WBC), polymorphonuclear (PMN), CRP and PCT by single factor analysis betwe