Giant cell tumor of extremities, surgical treatment and local adjuvants: which is the most effective?

Giant cell tumour (GCT) represents 5% of all primitive bone tumours. Standard surgical treatment of GCT includes intralesional excision or segmental resection. Curettage has a higher recurrence rate (10-25% in stage 2 or 3 but does preserve adjacent joint function. The use of local adjuvants such as...

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Bibliographic Details
Published inJournal of biological regulators and homeostatic agents Vol. 34; no. 5 Suppl. 1; p. 57
Main Authors Colangeli, S, Del Chiaro, A, Andreani, L, D'Arienzo, A, Parchi, P, Capanna, R
Format Journal Article
LanguageEnglish
Published Italy 01.09.2020
Subjects
Bone Neoplasms - surgery
Curettage
Extremities - surgery
Giant Cell Tumor of Bone - diagnostic imaging
Giant Cell Tumor of Bone - surgery
Humans
Hydrogen Peroxide
Neoplasm Recurrence, Local
Retrospective Studies
microbiota
recurrence
excision
Adjuvants
Cryoablation
Giant Cell Tumours
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Summary:Giant cell tumour (GCT) represents 5% of all primitive bone tumours. Standard surgical treatment of GCT includes intralesional excision or segmental resection. Curettage has a higher recurrence rate (10-25% in stage 2 or 3 but does preserve adjacent joint function. The use of local adjuvants such as phenol, alcohol, H2O2, Argon or cement may decrease recurrence rate, yet which local adjuvant works best is still, to this day, controversial. A series of 109 patients with GCT of the extremity, surgical treated in a single Institution from 2016 to 2018, were analysed in a retrospective study. The purpose of our study was to report the incidence of recurrence rate in patients with GCT of limbs treated in a single institution with different local adjuvants. The results of the present study suggests that curettage in association to cryoablation seems to reduce the recurrence rate compared to "classic" local adjuvants.
ISSN:0393-974X