Changes of CD4 + CD25 + Foxp3 + Regulatory T Cells in Different Stages of COPD and Intervention of Qibai Pingfei Capsules

• Published in: Zhong yao cai Vol. 37; no. 12; p. 2244
• Main Authors: Jiang, Hui, Li, Ze-geng, Gao, Jia-rong, Meng, Mei
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2014
• Subjects: Animals; Capsules; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Flow Cytometry; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - immunology; Rats; T-Lymphocyte Subsets - cytology; T-Lymphocyte Subsets - drug effects; T-Lymphocytes, Regulatory - cytology; T-Lymphocytes, Regulatory - drug effects
• ISSN: 1001-4454

To observe the changes in proportion of CD4 + CD25 + Foxp3 + regulatory T cells (Treg) in peripheral blood of different stages of CPOD and intervention of Qibai Pingfei Capsules. The rats were randomly divided into three groups,including normal group, COPD group and Qibai Pingfei Capsules(2. 88 g/kg)group. At the end of 7,14,21 and 28 days,eight rats were sacrificed in each group. CD4 + CD25 + Foxp3 + Treg cells in peripheral blood were measured by flow cytometry method. Compared with normal group, the percentages of CD4 + % in peripheral blood were not significantly different at the end of 7, 14, 21 and 28 days. However, CD4 + CD25 + % and CD4 + CD25 + Foxp3 +/CD4 + were significantly increased and CD4 + CD25 + Foxp3 + Treg% were significantly decreased at the end of 14,21 and 28 days. Compared with model group, CD4 + CD25 + %, CD4 + CD25 + Foxp3 +/CD4 + were significantly decreased, CD4 + CD25 + Foxp3 + Treg % were significantly increased at different stages of CODP. Immune disorders may exist in COPD, and