Clinicopathological analysis of aggressive angiomyxoma

To explore the clinicopathological characteristics of aggressive angiomyxoma (AAM) so as to boost the level of diagnosis and treatment. Seven cases of aggressive angiomyxoma were studied with light microscope and immunohistochemistry. Antibody of Vimentin, Desmin, CD34, smooth muscle actin (SMA), es...

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Bibliographic Details
Published inZhong hua yi xue za zhi Vol. 92; no. 22; p. 1553
Main Authors Wei, Hong-quan, Liu, Jun, Feng, Jing-jing
Format Journal Article
LanguageChinese
Published China 12.06.2012
Subjects
Adult
Aged
Female
Humans
Immunohistochemistry
Male
Middle Aged
Myxoma - pathology
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Summary:To explore the clinicopathological characteristics of aggressive angiomyxoma (AAM) so as to boost the level of diagnosis and treatment. Seven cases of aggressive angiomyxoma were studied with light microscope and immunohistochemistry. Antibody of Vimentin, Desmin, CD34, smooth muscle actin (SMA), estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), S-100, p53 and Ki67 were used. There were 3 males and 4 females with an average age of 43.1 years. Three patients had urinary compressive complaints while others were symptom-free. All underwent surgical resection. Three patients were recurrent after operation. The tumor was generally nodular and its cut surface appeared jelly-like. Histologically, on myxoid stroma background, it was composed of a mixture of spindle and stellar cells without atypical cell and mitosis. There were various-sized vessels with thin to thick walls. The scattered muscle-like cells had a perivascular distribution. Immunohistochemistry showed that tumor cells were pos
ISSN:0376-2491
DOI:10.3760/cma.j.issn.0376-2491.2012.22.013