The latest research advance in media involved in sepsis

• Published in: Zhonghua wei zhong bing ji jiu yi xue Vol. 28; no. 2; p. 188
• Main Authors: Hao, Yufang, Geng, Lixia
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2016
• Subjects: Adaptive Immunity; Cytokines - blood; Humans; Immunity, Innate; Inflammation - physiopathology; Intensive Care Units; Sepsis - immunology; Sepsis - physiopathology; Shock, Septic - immunology; Shock, Septic - physiopathology; Signal Transduction
• DOI: 10.3760/cma.j.issn.2095-4352.2016.02.021
• ISSN: 2095-4352

Sepsis and septic shock are the major causes of death in intensive care units (ICUs) worldwide. A large amount of studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines, proteases, lipid mediators, vasoactive peptides, and cell stress markers play key roles in pathophysiology of sepsis. Although anti-inflammatory mediators can neutralize the promoting role of pro-inflammatory mediators, but persistent immune regulation may cause host susceptibility to concurrent infections. Therefore, it is a great challenge to seek effective clinical therapy against sepsis. To understand the complicated interplay between pro- and anti-inflammatory agents in sepsis, and their interaction in signal transduction and immune regulation in sepsis constitute vital significance to the prevention and control of sepsis. Summarize the latest findings about mediators associated with sepsis and innate and adaptive immune system at h