The latest research advance in media involved in sepsis

Sepsis and septic shock are the major causes of death in intensive care units (ICUs) worldwide. A large amount of studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines, proteases, lipid mediat...

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Bibliographic Details
Published inZhonghua wei zhong bing ji jiu yi xue Vol. 28; no. 2; p. 188
Main Authors Hao, Yufang, Geng, Lixia
Format Journal Article
LanguageChinese
Published China 01.02.2016
Subjects
Adaptive Immunity
Cytokines - blood
Humans
Immunity, Innate
Inflammation - physiopathology
Intensive Care Units
Sepsis - immunology
Sepsis - physiopathology
Shock, Septic - immunology
Shock, Septic - physiopathology
Signal Transduction
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Summary:Sepsis and septic shock are the major causes of death in intensive care units (ICUs) worldwide. A large amount of studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines, proteases, lipid mediators, vasoactive peptides, and cell stress markers play key roles in pathophysiology of sepsis. Although anti-inflammatory mediators can neutralize the promoting role of pro-inflammatory mediators, but persistent immune regulation may cause host susceptibility to concurrent infections. Therefore, it is a great challenge to seek effective clinical therapy against sepsis. To understand the complicated interplay between pro- and anti-inflammatory agents in sepsis, and their interaction in signal transduction and immune regulation in sepsis constitute vital significance to the prevention and control of sepsis. Summarize the latest findings about mediators associated with sepsis and innate and adaptive immune system at h
ISSN:2095-4352
DOI:10.3760/cma.j.issn.2095-4352.2016.02.021