Outcome of Pulmonary Metastasectomy for Hepatocellular Carcinoma

Pulmonary metastasis of hepatocellular carcinoma (HCC) is considered a poor prognostic feature of the disease, and the utility of pulmonary resection is unclear. We evaluated clinical outcomes following pulmonary resection in 7 patients. All patients underwent video-assisted thoracic surgery (VATS)....

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 42; no. 12; p. 1494
Main Authors Ogawa, Toshihiro, Satoh, Daisuke, Matsukawa, Hiroyoshi, Araki, Hiroyuki, Shiozaki, Shigehiro, Kanazawa, Takashi, Harano, Masao, Ojima, Yasutomo, Idani, Hitoshi, Okajima, Masazumi, Ninomiya, Motoki, Fujiwara, Toshiya, Matsuura, Motoki
Format Journal Article
LanguageJapanese
Published Japan 01.11.2015
Subjects
Adult
Aged
Carcinoma, Hepatocellular - therapy
Female
Humans
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Lung Neoplasms - secondary
Lung Neoplasms - surgery
Male
Metastasectomy
Middle Aged
Pneumonectomy
Treatment Outcome
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Summary:Pulmonary metastasis of hepatocellular carcinoma (HCC) is considered a poor prognostic feature of the disease, and the utility of pulmonary resection is unclear. We evaluated clinical outcomes following pulmonary resection in 7 patients. All patients underwent video-assisted thoracic surgery (VATS). The median disease-free interval (DFI) was 14 (6-23) months. During pulmonary resection in 1 of the patients, intrahepatic recurrence was discovered and, 18 months later, this patient died of the recurrence. Of the remaining 6 patients, 2 patients developed intrahepatic recurrence and brain metastasis and died at 66 months and 10 months after pulmonary resection. Three patients are still alive and disease-free to date with a median follow-up duration of 42 (18-55) months. Of these 3 surviving patients, 2 patients had solitary pulmonary metastases and 1 patient had multiple bilateral pulmonary metastases; these patients underwent VATS once. The 7th patient underwent VATS 3 times for pulmonary metastasis and had no evidence of intrahepatic or extrahepatic recurrence. This patient died of an unrelated cause 15 months after the last pulmonary resection (47 months after the primary pulmonary resection). This study indicates that surgical resection of metachronous pulmonary metastases is associated with a favorable outcome in selected patients.
ISSN:0385-0684