The Correlation of Minimal Residual Disease with Prognosis in TCF3-PBX1 + Acute Lymphoblastic Leukemia in Children

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 28; no. 6; p. 1831
• Main Authors: Zhang, Li, Zou, Yao, Ai, Xiao-Fei, Cao, Zeng, Chen, Yu-Mei, Guo, Ye, Yang, Wen-Yu, Chen, Xiao-Juan, Wang, Shu-Chun, Liu, Xiao-Ming, Ruan, Min, Liu, Tian-Feng, Liu, Fang, Qi, Ben-Quan, Chang, Li-Xian, An, Wen-Bin, Ren, Yuan-Yuan, Li, Qing-Hua, Zhu, Xiao-Fan
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2020
• Subjects: Adolescent; Bone Marrow; Child; Child, Preschool; Female; Humans; Male; Neoplasm, Residual; Oncogene Proteins, Fusion - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2020.06.007

To investigate the consistency between FCM and PCR on the detecting of MRD in TCF3-PBX1 ALL, and to investigate the prognosis value of these 2 methods. 55 cases of paediatric TCF3-PBX1 ALL patients from April 2008 to April 2015 were enrolled and analyzed. The FCM and PCR was used to detect the MRD in 239 bone marrow samples of 55 patients. All statistical analyses were carried out by using SPSS software version 16. Among the 55 children with TCF3-PBX1 ALL, there were 30 male and 25 female. The median age was 5 (1-14) years. 20 patients relapsed during follow-up. The MRD results from PCR and FCM showed a strong correlation between both methods (K=0.774, P<0.001). There was no significant difference in 5-years DFS and OS between the patients in PCR and PCR groups on day 15 or day 33. The 5 year DFS rate between the patients in FCM and FCM was 63.9%±7.0% and 0; the 5 year OS rate was 66.5%±7.9% and 0. Combined with the result of FCM and PCR, at the d 33 of treatment, the 5-year DFS rate in FCM /PCR and single po