CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients

• Published in: Clinical and experimental rheumatology Vol. 32; no. 4 Suppl 84; pp. S72 - S74
• Main Authors: Bettencourt, Andreia, Leal, Bárbara, Carvalho, Cláudia, Oliveira, Rita, Martins Silva, Ana, Vaz Patto, José, Bastos, Marina, Costa, Luciana, Costa, Paulo P, Vasconcelos, Carlos, Correia, João, Silva, Berta M
• Format: Journal Article
• Language: English
• Published: Italy 01.07.2014
• Subjects: Adolescent; Adult; Aged; Behcet Syndrome - genetics; Behcet Syndrome - metabolism; Female; Gene Deletion; Genetic Predisposition to Disease - genetics; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Portugal; Receptors, CCR5 - genetics; Receptors, CCR5 - metabolism; Signal Transduction - genetics; Young Adult; Portugal
• ISSN: 0392-856X

To investigate whether CCR5 deletion is associated with susceptibility to Behçet's disease (BD) in a Portuguese population. A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing. No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences. These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.